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Microparticles (MPs) stimulate inflammatory adhesion molecule expression in systemic vascular diseases, however it is unknown whether circulating MPs stimulate localized ICAM-1 expression in the heterogeneically distinct pulmonary endothelium during pulmonary arterial hypertension (PAH).
Pulmonary vascular lesions with infiltrating inflammatory cells in PAH form in the pulmonary arteries and arterioles, but not the microcirculation.
Recent emphasis has been placed on the importance of infiltrating inflammatory cells in the formation of pulmonary vascular lesions.
These cells include macrophages, T and B lymphocytes, and mast cells.
All experimental procedures were approved by the Institutional Animal Care and Use Committee at the University of South Alabama (Protocol # 829408, PI Natalie Bauer; Association for Assessment and Accreditation of Laboratory Animal Care International approved since 1999; Compliance with Public Health Service Policy on Humane Care and Use of Laboratory Animals Assurance Number: A3288-01).
Adult male Sprague-Dawley rats (Harlan Laboratories, Inc.) weighing 200–225 g were randomly assigned to one of two treatment groups.
The implications of this work are that MPs in late-stage PAH are capable of inducing ICAM-1 expression selectively in the pulmonary artery.Therefore, we sought to determine whether circulating MPs from PAH stimulate pulmonary artery endothelial cell-selective ICAM-1 expression.